The Timelord must face the megalomaniac scientist, last seen entering an escape pod in 1988, in the final two episode of the long-running BBC1 show.
Now played by the Shakespearian actor Julian Bleach, the character plans to use his creations, the Daleks, to become the supreme ruler of the universe.
Created by screenwriter Terry Nation, he was first introduced in Genesis of the Daleks in 1975, and last appeared thirteen years later in Remembrance of the Daleks.
Horribly scarred and crippled after an explosion on his planet, Skaro, he had only one functioning arm and a robotic "eye" mounted on his forehead.
A master of robotics, the villain depended completely upon a self-designed mobile life-support chair which enclosed the lower half of his body.
This became the inspiration for his deadliest creation, and Dr Who's nemesis, the Daleks.
The return of his old enemy is not the only shock for the time-travelling Doctor, played in the current series by David Tennant.
Dr Who and his sidekick Rose, played by Billie Piper, are also faced with a new and deadly red Dalek.